Prague has evolved into a sophisticated hub for digital health innovation. Driven by excellent technical talent from universities like CTU and a strategic focus on the German and DACH markets, local founders are building regulated medical technologies rather than just lifestyle apps.
The ecosystem is defined by deep learning applications in diagnostics, digital therapeutics that get reimbursed by insurance, and hardware-software hybrids. These companies are not just modernising Czech healthcare, they are exporting medical precision worldwide.
Here are the 10 Health-Tech startups in Prague you need to watch in 2026.
Carebot
Matěj Misař and Daniel Kvak founded Carebot to serve as a second pair of eyes for radiologists and surgeons. Their AI-driven platform analyses chest X-rays and mammograms to detect findings that might be invisible to the human eye or missed due to fatigue. The system integrates directly with the hospital’s Picture Archiving and Communication System (PACS) to highlight abnormalities in real time. By achieving high accuracy in clinical validation, Carebot reduces diagnostic errors and speeds up workflows for overburdened medical staff in Czech hospitals.
Aireen
Jan Hlaváček and the team at Aireen are using the eye as a window into systemic health. They developed a certified medical device that uses artificial intelligence to screen for chronic diseases through retinal imaging. Their flagship product detects diabetic retinopathy in seconds during a standard eye exam, preventing blindness in diabetic patients. The technology enables general practitioners and diabetologists to perform screenings previously reserved for specialist ophthalmologists, effectively democratising access to critical preventive care.
Vitadio
Jan Šomvársky created Vitadio to treat Type 2 diabetes without relying solely on medication. This digital therapeutic app provides personalised lifestyle interventions based on patient data to improve glycemic control. Crucially, Vitadio achieved the gold standard of validation by becoming a certified digital health application (DiGA) in Germany. This means German doctors can prescribe the app, and statutory health insurance covers the cost. They are a prime example of a Czech startup successfully cracking the complex regulatory landscape of the Western European healthcare market.
VOS.health
Jiří Diblík and Ondřej Kopecký founded VOS.health to modernise mental health care through AI and psychology. The platform aggregates user data from wearables (such as Apple Watch) and combines it with mood tracking and journaling to generate personalised wellbeing plans. With over 3 million users worldwide, they have successfully pivoted to a B2B model, helping employers monitor and improve workforce mental health. Their AI advisors predict mood dips and offer interventions before a user reaches a crisis point, shifting mental health support from reactive to preventative.
Mindpax
Pavel Nevický founded Mindpax to solve the unpredictability of severe mental illness. The company creates a digital management system for patients with Bipolar Disorder and Schizophrenia. By combining a proprietary wrist sensor with a mobile app, they track biorhythms and activity levels to predict relapse events. This objective data allows psychiatrists to adjust medication dosage precisely and helps patients understand their own triggers. Their system significantly reduces hospitalisation rates by catching manic or depressive episodes early.
Meddi Hub
Jiří Pecina founded Meddi Hub to build the infrastructure for telemedicine in Central Europe and Latin America. Unlike simple video-call apps, Meddi offers a comprehensive digital clinic that integrates with hospital information systems and collects vitals from peripheral devices. They have secured major contracts to provide remote care to corporate clients and even to the military. Their platform encrypts and organises medical data, allowing doctors to treat patients remotely across borders with full legal and clinical compliance.
VR Medical
Konstantin Novikov created VR Medical to gamify the painful process of physical rehabilitation. They use Virtual Reality headsets to immerse patients in therapeutic exercises that aid recovery from strokes, injuries, or surgery. By turning repetitive movements into engaging games, they increase patient motivation and adherence to physiotherapy plans. The system provides therapists with precise data on range of motion and progress, making rehabilitation measurable and more efficient than traditional gym-based therapy.
Kardi AI
Stephen Burke founded Kardi AI to make long-term heart monitoring accessible and affordable. Cardiovascular diseases are often missed because short-term hospital ECGs fail to catch sporadic arrhythmias. Kardi AI provides a Polar chest strap wearable connected to an AI-powered app that allows patients to continuously monitor their heart. The AI filters out noise and flags irregularities to the patient’s cardiologist in near real-time. This continuous stream of medical-grade data enables doctors to diagnose conditions like Atrial Fibrillation faster and more cheaply than with implantable loop recorders.
Elonga
Vojtěch Hlaváček launched Elonga to bring longevity science to the mass market. The startup combines a biometric sensor (strap) with an app that measures heart rate variability (HRV) and readiness. Unlike standard fitness trackers, Elonga focuses on “biological age” and long-term vitality. They provide users with specific, science-backed plans to slow down ageing and improve metabolic health. By focusing on the preventive aspect of longevity, they appeal to biohackers and health-conscious professionals seeking actionable data on their internal health.
Fitify
Martin Mazanec and Matouš Skála built Fitify into a global fitness juggernaut from a dorm room in Prague. While often categorised as consumer fitness, their move into AI-driven physiotherapy and rehabilitation planning positions them firmly in health tech. Their app uses algorithms to build custom workout plans based on a user’s specific injuries, equipment, and goals. With over 15 million downloads, they leverage a massive dataset to optimise physical training protocols, bridging the gap between a personal trainer and a physical therapist.